1b50

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1b50

Contents 1 NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES 2 Function 3 About this Structure 4 Reference

NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES

Template:ABSTRACT PUBMED 10347159

Function

[CCL3_HUMAN] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).^[1]

About this Structure

1b50 is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Czaplewski LG, McKeating J, Craven CJ, Higgins LD, Appay V, Brown A, Dudgeon T, Howard LA, Meyers T, Owen J, Palan SR, Tan P, Wilson G, Woods NR, Heyworth CM, Lord BI, Brotherton D, Christison R, Craig S, Cribbes S, Edwards RM, Evans SJ, Gilbert R, Morgan P, Randle E, Schofield N, Varley PG, Fisher J, Waltho JP, Hunter MG. Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants. J Biol Chem. 1999 Jun 4;274(23):16077-84. PMID:10347159

1. ↑ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995 Dec 15;270(5243):1811-5. PMID:8525373