1h1i

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Template:STRUCTURE 1h1i

Contents 1 CRYSTAL STRUCTURE OF QUERCETIN 2,3-DIOXYGENASE ANAEROBICALLY COMPLEXED WITH THE SUBSTRATE QUERCETN 2 Function 3 About this Structure 4 See Also 5 Reference

CRYSTAL STRUCTURE OF QUERCETIN 2,3-DIOXYGENASE ANAEROBICALLY COMPLEXED WITH THE SUBSTRATE QUERCETN

Template:ABSTRACT PUBMED 12486225

Function

[QDOI_ASPJA] Performs the first step in the degradation of the flavonoid quercetin by a dioxygenase reaction. The enzyme catalyzes the cleavage of the O-heteroaromatic ring of the flavonol quercetin yielding the depside 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. This involves the remarkable dioxygenolytic cleavage of two carbon-carbon bonds.

About this Structure

1h1i is a 4 chain structure with sequence from Aspergillus japonicus. Full crystallographic information is available from OCA.

See Also

• Dioxygenase

Reference

• Steiner RA, Kalk KH, Dijkstra BW. Anaerobic enzyme.substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16625-30. Epub 2002 Dec 16. PMID:12486225 doi:10.1073/pnas.262506299