2e6a

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Template:STRUCTURE 2e6a

Contents 1 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate

Function

[Q4D3W2_TRYCR] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

About this Structure

2e6a is a 2 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

See Also

• Dihydroorotate dehydrogenase

Reference

• Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. Biochemistry. 2008 Oct 14;47(41):10881-91. Epub 2008 Sep 23. PMID:18808149 doi:10.1021/bi800413r