1ud0

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Template:STRUCTURE 1ud0

Contents

CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70

Template:ABSTRACT PUBMED 12773536

Function

[HSP7C_RAT] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).

About this Structure

1ud0 is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Chou CC, Forouhar F, Yeh YH, Shr HL, Wang C, Hsiao CD. Crystal structure of the C-terminal 10-kDa subdomain of Hsc70. J Biol Chem. 2003 Aug 8;278(32):30311-6. Epub 2003 May 28. PMID:12773536 doi:10.1074/jbc.M304563200

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OCA

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