1rpq

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Template:STRUCTURE 1rpq

Contents

High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display

Template:ABSTRACT PUBMED 15242605

Function

[FCERA_HUMAN] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

About this Structure

1rpq is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Stamos J, Eigenbrot C, Nakamura GR, Reynolds ME, Yin J, Lowman HB, Fairbrother WJ, Starovasnik MA. Convergent recognition of the IgE binding site on the high-affinity IgE receptor. Structure. 2004 Jul;12(7):1289-301. PMID:15242605 doi:10.1016/j.str.2004.04.015

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