2ix7

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 2ix7

Contents 1 Structure of apo-calmodulin bound to unconventional myosin V 2 Function 3 About this Structure 4 See Also 5 Reference

Structure of apo-calmodulin bound to unconventional myosin V

Template:ABSTRACT PUBMED 17151196

Function

[MYO5A_MOUSE] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.^[1]

About this Structure

2ix7 is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

• Calmodulin
• Myosin

Reference

• Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C. Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:17151196

1. ↑ Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012 Aug 20;198(4):545-60. doi: 10.1083/jcb.201111091. PMID:22908308 doi:10.1083/jcb.201111091