1yqk

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1yqk

Contents 1 Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA

Template:ABSTRACT PUBMED 15800616

Disease

[OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

Function

[OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

About this Structure

1yqk is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• DNA glycosylate

Reference

• Banerjee A, Yang W, Karplus M, Verdine GL. Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature. 2005 Mar 31;434(7033):612-8. PMID:15800616 doi:10.1038/nature03458