4j3e

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Template:STRUCTURE 4j3e

Contents

The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a

Template:ABSTRACT PUBMED 23400593

Function

[MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

About this Structure

4j3e is a 1 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8. Epub 2004 Jan 2. PMID:14704432 doi:10.1126/science.1092472

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