Publication Abstract from PubMed
The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution. Comparison with computational models revealed deviations in a few framework positions and in the binding loops. The crystals belong to space group P2(1)2(1)2 and contain four molecules in the asymmetric unit, with unit-cell parameters a=102.77, b=185.92, c=102.97 A. These particular unit-cell parameters allowed pseudo-merohedral twinning; interestingly, the twinning law relates a twofold screw axis to a twofold axis.
Structure of the recombinant antibody Fab fragment f3p4.,Frey D, Huber T, Pluckthun A, Grutter MG Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):636-43. Epub 2008 May 14. PMID:18560151[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
