3bsu

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Template:STRUCTURE 3bsu

Contents

Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA

Template:ABSTRACT PUBMED 18337749

Function

[RNH1_HUMAN] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

About this Structure

3bsu is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W. Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. EMBO J. 2008 Apr 9;27(7):1172-81. Epub 2008 Mar 13. PMID:18337749 doi:10.1038/emboj.2008.44

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OCA

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