1jmw

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Image:1jmw.jpg

1jmw, resolution 1.9Å

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Propagating Conformational Changes Over Long (And Short) Distances

Overview

The problem of the propagation of conformational changes over long distances or through a closely packed protein is shown to fit a model of a ligand-induced conformational change between two protein states selected by evolution. Moreover, the kinetics of the pathway between these states is also selected so that the energy of ligand binding and the speed of the transition between conformational states are physiologically appropriate. The crystallographic data of a wild-type aspartate receptor that has negative cooperativity and a mutant that has no cooperativity but has native transmembrane signaling are shown to support this model.

About this Structure

1JMW is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Propagating conformational changes over long (and short) distances in proteins., Yu EW, Koshland DE Jr, Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9517-20. PMID:11504940

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