2ykm

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Image:2ykm.png

Template:STRUCTURE 2ykm

Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI)

Template:ABSTRACT PUBMED 22017513

About this Structure

2ykm is a 2 chain structure with sequence from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

Reference

  • Boyer J, Arnoult E, Medebielle M, Guillemont J, Unge J, Jochmans D. Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. J Med Chem. 2011 Dec 8;54(23):7974-85. Epub 2011 Nov 4. PMID:22017513 doi:10.1021/jm200766b

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