Alkaline phosphatase

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Template:STRUCTURE 1elx

Alkaline phosphatase (ALP) is an enzyme which removes phosphate from nucleotides, proteins and alkaloids. The enzyme is most effective in alkaline environment.


3D Structures of alkaline phosphatase

Updated on 29-January-2014

1alk, 1ed9, 1ed8 – EcALP + Zn + Mg – Eschechia coli
3bdh - EcALP + Mg
1aja, 3bdf, 3bdg – EcALP (mutant)
1ali, 1ajb, 1ajc, 1ajd, 1alj, 1ani, 1anj, 2anh, 1hqa, 1urb, 1hjk, 1khk, 1kh7 - EcALP (mutant) + Zn + Mg
1ura - EcALP (mutant) + Zn
1khn - EcALP (mutant) + Zn
1b8j - EcALP + Zn + Mg + VO4
1kh5 - EcALP (mutant) + Zn + Mg + AlF3
1khj - EcALP (mutant) + Zn + AlF3
1k7h – nsALP + Zn + maleic acid – northern shrimp
1shq - nsALP + Zn + Mg
1zeb - hALP + Zn + Mg – human
1zef - hALP + Zn + Mg + phenylalanine
2glq - hALP + Zn + Mg + Sr
3e2d – ALP + Zn + Mg – Vibrio
3a52 - ALP + Zn + Mg – Shewanella
3q3q - ALP + Zn + Ca – Sphingomonas
2yeq - ALP D + Fe + Ca – Bacillus subtilis
3zwu - PfALP Phox + Fe2O + VO4 – Pseudomonas fluorescens
4a9v - PfALP Phox + Fe2O + Ca

ALP complexes with phosphate derivative

1khl, 3dyc, 4km4 - EcALP (mutant) + Zn + phosphate
1alh, 3tg0 - EcALP + Zn + phosphate
1y6v - EcALP + Co + phosphate
1y7a - EcALP (mutant) + Co + phosphate
1elx, 1ely, 1elz, 1kh9, 1kh4, 2g9y, 3cmr - EcALP (mutant) + Zn + Mg + phosphate
3dpc - EcALP (mutant) + phosphorylated peptide
2ga3 - EcALP (mutant) + Zn + Mg + phosphothreonine
1ew8 - EcALP + Zn + phosphonoacetic acid + phosphate
1ew9 - EcALP + Zn + Mg + mercaptomethyl phosphonate
1shn - nsALP + Zn + phosphate
1zed - hALP + Zn + Mg + PO3 + nitrophenyl hydrogen methylphosphonate
3mk0, 3mk1 - hALP + Zn + Mg + phosphate + nitrophenol + phosphoserine
3mk2 - hALP + Zn + Mg + phosphoserine
2iuc - AbALP + Zn + Mg + phosphate – Antarctic bacterium
2w5v, 2w5x - AbALP (mutant) + Zn + Mg + phosphoserine
2w5w - AbALP (mutant) + Zn + phosphoserine
2x98 - ALP + Zn + Mg + phosphate – Halobacterium salinarum
4a9x - PfALP Phox + Fe2O + Ca + A[β,γ-methylene]TP
4alf - PfALP Phox + Fe2O + Ca + phosphate
4kjd - rALP + Mg + phosphoserine – rat
4kjg - rALP + Zn + Mg + nitrophenyl phosphate

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Michal Harel, Alexander Berchansky

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