Molecular Playground/IntegrinBeta1

From Proteopedia

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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Molecular Playground banner: "

Banner: Integrin Beta 1 binds to ECM proteins and allows for 3D in vitro cell migration

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Contents 1 Structure 2 Function 3 Disease 4 Studying Integrin Beta-1 in vitro 5 Peyton Lab Research Interests 6 References

Structure

Here are the

Function

Integrins are a class of surface proteins that bind to extra cellular matrix components and transmit chemical and mechanical cues to internal signaling pathways. Integrin beta 1 binds many proteins when dimerized with an alpha subunit, including collagen, laminin and fibronectin.

Disease

Studying Integrin Beta-1 in vitro

Peyton Lab Research Interests

The Peyton lab studies how cells process chemical and physical cues from the extracellular matrix, and how these interactions play a role in disease progression. By creating synthetic microenvironments, we are able to have tight control of cell-matirx interactions, allowing us to better understand how cells use their integrins to bind to matrix, and what downstream signaling pathways this binding sets off.

References