Chitinase

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Chitinases cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium (1ctn) and a plant (2hvm). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed.

3D Structures of Chitinase

Updated on 20-November-2014 Chitinase-3-like protein 1

• Chitinase I

• • 3aro, 3b8s – VhChi residues 22-597 – Vibrio harveyi
    
  • 3b9e - VhChi residues 22-597 (mutant)
    
  • 1k85 – BcChi fibronectin domain – Bacillus circulans – NMR
    
  • 1itx - BcChi catalytic domain
    
  • 1ed7 – BcChi chitin-binding domain - NMR
    
  • 1ll6, 1ll7 - CiChi residues 36-427 (mutant) – Coccicioides immitis
    
  • 1d2k - CiChi residues 36-427
    
  • 3n11 – BcChi – Bacillus cereus
    
  • 3iwr, 2dkv – Chi residues 33-340 – Japanese rice
    
  • 1edq, 1ctn, 4axn - SmChi – Serratia marcescens
    
  • 1x6l, 1rd6 – SmChi (mutant)
    
  • 3g6l - BoChi residues 21-426 – Bionectria ochroleuca
    
  • 3oa5, 4dws – Chi – Yersinia entomophaga
    
  • 3w4r – Chi – corn borer
    

• Chitinase I binary complex

• • 3arp, 3arq, 3arr, 3ars, 3art, 3aru, 3arv, 3arw, 3arx, 3ary, 3arz – VhChi residues 22-597 + inhibitor
    
  • 3as0, 3as1, 3as2, 3as3 – VhChi residues 22-597 (mutant) + inhibitor
    
  • 3b9a, 3b9d - VhChi residues 22-597 + polysaccharide
    
  • 2xvn, 2xuc – AfChi residues 29-307 + inhibitor – Aspergillus fumigatus
    
  • 3n13, 3n15, 3n17, 3n18 – BcChi (mutant) + NAG
    
  • 3n12 – BcChi + Zn
    
  • 3n1a - BcChi (mutant) + inhibitor
    
  • 1x6n - SmChi (mutant) + inhibitor
    
  • 1ffq - SmChi + inhibitor
    
  • 1nh6, 1k9t, 1ffr, 1eib, 1ehn - SmChi (mutant) + polysaccharide
    
  • 2wk2, 2wly, 2wlz, 2wm0 – SmChi residues 2-520 + inhibitor
    
  • 3g6m - BoChi residues 21-426 + caffeine
    
  • 1waw, 1wb0 – hChi catalytic domain polypeptide – human
    
  • 1hkk, 1hkm, 3rm4, 3rm8, 3rm9, 3rme – hChi catalytic domain inhibitor
    
  • 1ll4 - CiChi residues 36-427 + inhibitor
    

• Chitinase II

• • 1e15, 3wd0 - SmChi
    
  • 1ogb, 1goi, 1e6p - SmChi (mutant)
    
  • 1kfw – Chi catalytic domain – Arthrobacter
    
  • 1dxj – Chi – Jack bean
    

• Chitinase II binary complex

• • 1ogg, 1ur9 - SmChi (mutant) + inhibitor
    
  • 1e6n - SmChi (mutant) + polysaccharide
    
  • 1ur8, 1gpf, 1e6r, 3wd1, 3wd2, 3wd3, 3wd4 - SmChi + inhibitor
    
  • 1e6z – SmChi + intermediate
    
  • 2a3a, 2a3b, 2a3c, 2a3e – AfChi + inhibitor
    
  • 1w1p, 1w1t, 1w1v, 1w1y, 1o6i, 1h0g, 1h0i – SmChi + polypeptide
    

• Chitinase III

• • 2dbt, 1wvu – SgChi residues 30-294 – Streptomyces griseus
    
  • 1wvv - SgChi residues 30-294 (mutant)
    
  • 2d49 – SgChi chitin-binding domain - NMR
    
  • 2xvp – AfChi
    
  • 2xtk – AfChi + inhibitor

• Chitinase IV

• • 3hbd, 3hbe, 3hbh - Chi catalytic domain – Norway spruce
    

• Chitinase V

• • 3alf – tChi residues 26-377 – tobacco
    

• Chitinase V binary complex

• • 3alg - tChi residues 26-377 (mutant) + NAG
    
  • 3chc, 3chd, 3che, 3chf - AfChi + polypeptide
    
  • 3ch9, 2iuz – AfChi + inhibitor
    

• Chitinase VIII

• • 2cjl - Chi residues 41-244 – Streptomyces coelicolor
    

• Chitinase XVIII

• • 3sim – Chi – Crocus vernus

• Chitinase C

• • 4dyg – RyChiC + NAG – Rye
    
  • 4dwx - RyChiC
    
  • 4j0l – RyChiC + GlcNAC
    

• Other chitinases

• • 1wno, 1w9p - AfChi
    
  • 2dsk - PfChi catalytic domain – Pyrococcus furiosus
    
  • 3afb - PfChi catalytic domain (mutant)
    
  • 1cns – Chi – Hordeum vulgare
    
  • 2czn - PfChi chitin-binding domain – NMR
    
  • 2cwr - PfChi chitin-binding domain
    
  • 3ian – Chi (mutant) – Lactococcus lactis
    
  • 3fxy - hChi catalytic domain
    
  • 1lq0 - hChi residues 22-286
    
  • 1guv - hChi residues 22-387
    
  • 3fnd, 3co4 – Chi – Bacteroides thetaiotamicron
    
  • 3cql – Chi – Carica papaya
    
  • 2z37 - BjChi catalytic domain – Brassica juncea
    
  • 2z39 – BjChi catalytic domain (mutant)
    
  • 2uy2 – yChi residues 22-315 – yeast
    
  • 4hmc – MmChi 60 – Moritella marina
    
  • 3w3e – Chi – cowpea
    
  • 3w6b – RaChi catalytic domain – Ralstonia
    
  • 3w6e – RaChi catalytic domain (mutant)
    

• Other chitinases binary complex

• • 3a4w, 3a4x – PfChi catalytic domain (mutant) + NAG
    
  • 1lg1 - hChi residues 22-387 + chitobiose
    
  • 1lg2 - hChi residues 22-387 + ethylene glycol
    
  • 3fy1, 2ybt, 2ybu - hChi catalytic domain + inhibitor
    
  • 1hki, 1hkj - hChi + inhibitor
    
  • 2z38 - BjChi catalytic domain + Cl
    
  • 2uy3, 2uy4, 2uy5 - yChi residues 22-315 + inhibitor
    
  • 1w9v, 1w9u - AfChi + polypeptide
    
  • 4hmd – MmChi 60 + intermediate
    
  • 4hme – MmChi 60 + NAG
    
  • 3w6c – RaChi catalytic domain + disaccharide
    
  • 3w6d, 3w6f – RaChi catalytic domain (mutant) + polysaccharide
    

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