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Contents 1 Haptoglobin-Hemoglobin Structure 2 Function 3 Disease 4 Relevance 5 Structural highlights 6 References

Haptoglobin-Hemoglobin Structure

Haptoglobin 1-1 (Hp), an abundant glycoprotein in blood binds free hemoglobin (Hb) dimers in one of the strongest non-covalent binding events known in biology.

Function

During intravascular hemolysis Hb which is physiological a is released from red blood cells in to the extracellular environment. Hb then dissociates into dimer exposing . Hp binds shields Hb and shields these redox active residues and exposes and epiptope recognized by the multifunctional receptor, CD163.

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Disease

Intravascular hemolysis is implicated in various diseases

Relevance

Structural highlights

(http://www.umass.edu Igor)

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References

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