Glyoxalase

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Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism.

• GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
  
• GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.

Contents 1 3D structures of glyoxalase 1.1 Glyoxalase 1 1.2 Glyoxalase 2 1.3 Glyoxalase 3

3D structures of glyoxalase

Updated on 27-August-2014

Glyoxalase 1

1bh5 – hGLO (mutant) – human
1fa8 – EcGLO – Escherichia coli
2c21 – GLO – Leishmania major
1fro – hGLO + benzyl glutathione
1qin, 1qip - hGLO + glutathione derivative
1f9z, 1fa5, 1fa6, 1fa7 – EcGLO + metal
2za0 – GLO + methyl gerfelin – mouse
3hdp – GLO + Ni – Clostridium acetobutylicum

Glyoxalase 2

1xm8 – GLO – Arabidopsis thaliana
2p18 - LiGLO – Leishmania infantum
1qh3 – hGLO + actate + cacodylate
1qh5 – hGLO + glutathione derivative
2p1e – LiGLO + lactate

Glyoxalase 3

4lru – GLO – Candida albicans