Interleukin receptor

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Template:STRUCTURE 2b5i Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).

3D structures of interleukin receptor

Updated on 30-November-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

Interleukin receptor type I

• Interleukin-2 receptor

• • 1z92 – hIL2R α subunit + interleukin-2
    
  • 2b5i - hIL2R α+β+γ subunits + interleukin-2
    
  • 3qaz - hIL2R β+γ subunits + interleukin-2
    
  • 2erj - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)
    
  • 3qb7 - hIL2R γ (mutant) subunit + interleukin-2
    
  • 3iu3, 3nfp - hIL2R α subunit + antibody

• Interleukin-4 receptor

• • 1iar - hIL4R α (mutant) subunit + interleukin-4
    
  • 3bpl - hIL4R α + γ subunits + interleukin-4
    
  • 3bpn - hIL4R α subunit + hIL13R α subunit + interleukin-4
    
  • 3bpo - hIL4R α subunit + hIL13R α subunit + interleukin-13

• Interleukin-5 receptor

• • 3qt2 – hIL5R α (mutant) subunit + interleukin-5
    
  • 3va2 - hIL5R α subunit + interleukin-5
    

• Interleukin-6 receptor or gp130

• • 1i1r – hIL6R β subunit + interleukin-6 homolog
    
  • 1pvh - hIL6R β subunit + leukemia inhILbitory factor
    
  • 2hmh - mI6R β subunit + suppressor of cytokine signaling 3 – mouse
    
  • 4gl9 - mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase
    
  • 3l5i, 3l5j, 3l5h - hIL6R β subunit
    
  • 1n26 - hIL6R α subunit
    
  • 2arw - hIL6R α subunit - NMR
    
  • 1p9m - hIL6R α + β subunits + interleukin-6

• Interleukin-7 receptor

• • 3up1 - hIL7R α subunit
    
  • 3di2, 3di3 – hIL7R α (mutant) subunit + interleukin-7 (mutant)

• Interleukin-13 receptor

• • 3lb6 - hIL13R α2 (mutant) subunit + interleukin-13
    
  • 4hwb - hIL13R α1 subunit + antibody
    

• Interleukin-15 receptor

• • 2ers - hIL15R α subunit sushIL domain – NMR
    
  • 2z3q, 2z3r, 2psm - hIL15R α subunit + interleukin-15
    
  • 4gs7 - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits
    

• Interleukin-17 receptor

• • 3jvf - hIL17RA extracellular domain + interleukin-17F
    
  • 4hsa - hIL17RA (mutant) + interleukin-17A
    
  • 3vbc – mIL17RB
    

• Interleukin-21 receptor

• • 3tgx – hIL21R extracellular domain (mutant) + interleukin-21

Interleukin receptor type II

• Interleukin-10 receptor

• • 1j7v – hIL10R α (mutant) subunit + interleukin-10
    
  • 1lqs, 1y6m, 1y6n - hIL10R α (mutant) subunit + interleukin-10 homolog
    
  • 1y6k - hIL10R α (mutant) subunit + interleukin-10
    
  • 3lqm - hIL10R β (mutant) subunit

• Interleukin-20 receptor

• • 4doh - hIL20R α,β subunit + interleukin-20
    

• Interleukin-22 receptor

• • 3g9v - hIL22R α subunit + interleukin-22
    
  • 3dgc – hIL22R α (mutant) subunit + interleukin-22
    
  • 3dlq - hIL22R α (mutant) subunit + interleukin-2 (mutant)

• Interleukin-28 receptor

• • 3og4, 3og6 - hIL28R α subunit + interleukin-29
    

Interleukin receptor of immunoglobulin family

• Interleukin-1 receptor (CD121a, CD121b)

• • 1itb – hI1R1 extracellular domain + interleukin-1 β – human
    
  • 1ira- hI1R1 extracellular domain + I1R1A
    
  • 1g0y - hI1R1 extracellular domain + I1R1A peptide
    
  • 3o4o - hI1R2 + interleukin-1 β
    
  • 4dep – hIL1R1 extracellular domain + interleukin-1 β + + interleukin-1 accessory protein
    
  • 4gaf – hIL1R1 extracellular domain + IL1β/IL1RA