Malate synthase (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. MS G is formed during growth on glycolate and MS A which metabolizes glyoxylate formed in the dissimilation of acetate.
3d structures of malate synthase
Updated on 24-March-2014
Malate synthase
1y8b, 2jqx – EcMS G (mutant) – Escherichia coli - NMR
3cuz, 3cv1 – EcMS A
4ex4 – MS G + Mg – Mycobacterium leprae
3cux – MS + Mg – Bacillus anthracis
Malate synthase binary complex
1d8c – EcMS G (mutant) + glyoxylate + Mg
3cv2 – EcMS A + oxalate + Mg
1n8i – MtMS G + glyoxylate + Mg – Mycobacterium tuberculosis
3oyx, 3pug – HvMS + glyoxylate + Mg – Haloferax volcanii
3s9i, 3s9z, 3sad, 3saz, 3sb0 – MtMS G (mutant) + inhibitor + Mg
Malate synthase ternary complex
1p7t – EcMS G (mutant) + pyruvate + Mg + acetyl-CoA
3oyz – HvMS + pyruvate + Mg + acetyl-CoA
1n8w – MtMS G + glyoxylate + Mg + CoA
2gq3 – MtMS G + malate + Mg + CoA
