MECDP synthase

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MECDP synthase (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. MECPS is a potential antimalarial drug target.

1 3D structures of MECDP synthase

3D structures of MECDP synthase

Updated on 19-August-2014

MECPS

1knk - EcMECPS + Mn – Escherichia coli
1u3p - EcMECPS + Zn
3f0d - BpMECPS + Zn – Burkholderia pseudomallei
3f0e - BpMECPS + Mg + Zn
1jn1 - HiMECPS + Co – Haemophilus influenzae
1vh8 - HiMECPS
1vha - HiMECPS + Mn
1iv1 - TtMECPS – Thermus thermophilus
3f6m - YpMECPS – Yersinia pestis
1iv3 - TtMECPS (mutant) + Mg
3ghz - MECPS + Mg – Salmonella typhimurium
3re3 - MECPS – Francisella tularensis
4c82 - PfMECPS (mutant) + Zn – Plasmodium falciparum

MECPS binary complex

1gx1 - EcMECPS + CDP + Mn + Zn
1u3l - EcMECPS + CDP + Mg + Zn
3f0f - BpMECPS + CMP + Mg + Zn
3ike - BpMECPS + cytosine + Mg + Zn
3k2x, 3ke1 - BpMECPS + cytosine derivative + Zn
3ikf, 3k14, 3q8h - BpMECPS + imidazo-thiazol derivative + Zn
3f0g, 3ieq - BpMECPS + CMP + Zn
2uzh - MECPS + CDP + Zn – Mycobacterium smegmatis
4c81 - PfMECPS (mutant) + CDP + Zn
3fpi - YpMECPS + CTP + Mg
1iv2 - TtMECPS (mutant) + CDP + Mg
1iv4 - TtMECPS (mutant) + CMP + Mg
1h47 - EcMECPS + CMP + Zn
3jvh - BpMECPS + pyrimidine derivative + Zn
1u40 - EcMECPS + CDME + Zn
1u43 - EcMECPS + 2P-CDME
1t0a - MECPS + farnesyl phosphate + Co + Zn - Shewanella oneidensis
2pmp - MECPS + CMP + Zn – Arabidopsis thaliana
4c8e, 4c8g - BcMECPS + CMP + Zn – Burkholderia cenocepacia
4c8i - BcMECPS + citrate + Zn

MECPS ternary complex

3iew - BpMECPS + CDP + CTP + Zn
1jy8 – EcMECPS + MECP + CMP + Zn
1knj - EcMECPS + MECP + CMP + Mn
3mbm - BpMECPS + imidazo-thiazol derivative +cytosine + Zn
3p10 - BpMECPS + pyrimidine derivative + cytidine + Zn
3t80 - MECPS + pyrimidine derivative + cytidine + Zn – Salmonella enterica
1yqn – EcMECPS (mutant) + CMP + geranyl diphosphate + Mn + Zn
2amt - EcMECPS + CMP derivative + geranyl diphosphate + Zn
3elc, 3eor, 3ern, 3fba - EcMECPS + pyrimidine derivative + geranyl diphosphate + Zn
3esj - EcMECPS + pyrimidine derivative + geranyl diphosphate + Mg + Zn
2gzl - EcMECPS + inhibitor + geranyl diphosphate + Zn