Nitroreductase

From Proteopedia

Template:STRUCTURE 1f5v

Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO₂ group. The NO₂ group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.

3D structures of nitroreductase

Updated on 02-September-2014

1f5v , 1oo5 – EcNR – Escherichia coli
3bm1, 1ds7 – EcNR minimal
3bm2 – EcNR minimal -FMN
1nec, 1kqd – EclNR – Enterobacter cloacae
1ywq, 2i7h – NR – Bacillus cereus
2b67 – NR – Streptococcus pneumonia
3ek3, 3hoi – NR – Bacterioides fragilis
3g14 – NR – Clostridium novyi
3h4o, 3koq - NR – Clostridium difficile
3gr3 – NR – Bartonella henselae
3hzn – NR – Salmonella typhimurium
3k6h – NR – Agrobacterium tumefaciens
2wqf – NR – Lactococcus lactis
2wzv, 2ymv – MsNR – Mycobacterium smegmatis
3of4 – NR FMN/FAD – Idiomarina loihiensis
3n2s – NR – Bacillus subtilis
3pxv – NR – Desulfitobacterium hafniense
3qdl – NR – Helicobacter pylori
3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
3r5r, 3r5w – MtNR F420

Nitroreductase binary complex

1kqb – EclNR + benzoate
1kqc – EclNR + acetate
1ylr, 1ylu - EcNR + acetate
1icr, 1icu, 1icv – EcNR + nicotinic acid
1ooq – EcNR + dicoumarol
1oo6, 1oon, 1idt – EcNR + benzamide derivative
1yki – EcNR + antibiotic
2wzw - MsNR + NADPH