NK cell receptor

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Template:STRUCTURE 1kcg

Natural killer (NK) cell receptors are located on the innate immune system NK cells. The receptors are differentiated into activating and inhibitory ones. The receptors induce apoptosis upon binding ligands which indicate infection.

Contents 1 3D structures of NK cell receptor 2 Activating NK cell receptors 2.1 NKG2D 2.2 NKP 2.3 2B4 2.4 Ly49 2.5 CD94 3 Inhibitory NK cell receptors 3.1 KIR

3D structures of NK cell receptor

Updated on 26-August-2014

Activating NK cell receptors

NKG2D

1hq8 – mNKG2D extracellular domain – mouse
1mpu – hNKG2D extracellular domain – human
1hyr – hNKG2D extracellular domain + class I MHC-like ligand MICA
1kcg – hNKG2D extracellular domain + class I MHC-like ligand ULBP3
4pp8 – mNKG2D extracellular domain + retinoic acid early-inducible protein 1β
4pdc – hNKG2D extracellular domain + cowpox virus protein
3bdw – hNKG2D extracellular domain + CD94
3bdw, 3cii – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen

NKP

1hkf – hNKP44 IG domain
1oll, 1p6f – hNKP46 extracellular domain

2B4

1z2k – h2B4 D1 domain - NMR
2ptu – m2B4 D1 domain
2ptt – h2B4 D1 domain + CD48 antigen

Ly49

3g8l, 3g8k – mLy49 C-type lectin-like domain

CD94

See CD94

Inhibitory NK cell receptors

KIR

3vh8 – hKIR extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region
3wuw – hKIR extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide