Hp is a class I human pathogen that can survive and colonize under acidic conditions of human stomach, prolonged exposure to which can result in gastric cancers. It requires two nickel dependent enzymes - Urease and NiFe-H2ase, to colonize and survive in acidic human stomach. Essentially, the Ni-metallochaperone, UreE is required for the maturation of Urease, which catalyzes the conversion of urea to ammonia and carbamate.
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In the Maroney
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