Function
Phosphatidylinositol-specific phospholipase C (PIPLC) catalyzes the hydrolysis of phosphatidylinositol into inositol triphosphate and deacylglycerol. PIPLC functions at the plasma membrane. PIPLC can release phosphatidylinositol-linked proteins (i.e., acetylcholinesterase) from the membrane by enzymatically cleaving their GPI anchor.
Disease
Relevance
Structural highlights
3D structures of phosphatidylinositol-specific phospholipase C
Updated on 02-September-2014
PIPLC
1ptd – BcPIPLC – Bacillus cereus
2ptd, 3ptd, 4ptd, 5ptd, 6ptd, 7ptd – BcPIPLC (mutant)
2plc – LmPIPLC – Listeria monocytogenes
3ea1 – BtPIPLC – Bacillus thuringiensis
1t6m, 2or2, 3ea3 – BtPIPLC (mutant)
3v18 – SaPIPLC – Staphylococcus aureus
4f2t, 4f2u, 4i8y, 4i9m – SaPIPLC (mutant)
PIPLC complex
1ptg – BcPIPLC + myo-inositol
1gym – BcPIPLC + glucosamine-myo-inositol
1aod – LmPIPLC + myo-inositol
3ea2 – BtPIPLC + myo-inositol
3v16, 4f2b – SaPIPLC + myo-inositol
3v1h, 4i9t – SaPIPLC (mutant) + myo-inositol
4i90 – SaPIPLC (mutant) + choline
4i9j – SaPIPLC (mutant) + diC4PC
References