Phosphoribosyltransferase
From Proteopedia
Phosphoribosyltransferase (PRT) are transferases which belong to several classes:
1. Hypoxanthine-guanine PRT (HGPRT). HGPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine.
2. Orotate PRT (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP).
3. Quinolinic acid PRT (QAPRT ). QAPRT is a degrading enzyme found in the brain.
4. Uracil PRT (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP.
5. Nicotinate nucleotide dimethylbenzimidazole PRT (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis.
6. Anthranilate PRT (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate.
7. ATP PRT participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate.
8. Nicotinate PRT (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate.
9. Nicotinamide PRT (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate.
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3D structures of phosphoribosyltransferase
Updated on 20-August-2014
Orotate PRT
1oro - EcOPRT – Escherichia coli
1j7j - StOPRT – Salmonella typhimurium
2aee - OPRT – Streptococcus pyogenes
3dez - OPRT – Streptococcus mutans
2yzk – OPRT – Aeropyrum pernix
2pry - yOPRT – yeast
3m3h - BaOPRT – Bacillus anthracis
3mjd - OPRT – Francisella tularensis
3n2l - VcOPRT – Vibrio cholera
3qw3, 3qw4 - OPRT – Leishmania infantum
2p1z – OPRT – Corynebacterium diphtheriae
4fym - PfOPRT – Plasmodium falciparum
4ohc – OPRT – Burkholderia cenocepacia
Orotate PRT complex
1sto– StOPRT + OMP
2prz - yOPRT + OMP
2qcn, 2wns, 3l0k, 3l0n, 3mo7 – hOPRT + UMP derivative
3mi2 - hOPRT + pyrazofurin monophosphate
4hib, 4hkp - hOPRT + inhibitor
3osc - BaOPRT + PRPP
1opr, 1lh0 - StOPRT + orotate + PRPP
2ps1 - yOPRT + orotate + PRPP
Hypoxanthine-guanine PRT
1nul, 1grv - EcHGPRT
1dbr - TgHGPRT – Toxoplasma gondii
1tc1 - TcHGPRT – Trypanosoma cruzi
1r3u - TteHGPRT – Thermoanaerobacter tengongensis
2geb - TteHGPRT (mutant)
1vdm - PhHGPRT – Pyrococcus horikoshii
1z7g - hHGPRT
3h83, 3hvu, 3o7m - BaHGPRT
3acb - TtHGPRT – Thermus thermophilus
3ohp - VcHGPRT
4lyy – HGPRT – Shewanella pealeana
Hypoxanthine-guanine PRT binary complex
1a98, 1a97 - EcHGPRT (mutant) + GMP
1g9s - EcHGPRT + IMP
1g9t - EcHGPRT + GMP
1hmp, 2vfa - hHGPRT + GMP
3gep, 3ggj - hHGPRT + guanine derivative
3ggc - hHGPRT + hypoxanthine derivative
4ijq - hHGPRT + inhibitor
4kn6 - hHGPRT + antiviral agent
1hgx - HGPRT + GMP – Tritrichomonas foetus
1qk3 - TgHGPRT + GMP
1qk4 - TgHGPRT + IMP
1p19 - TcHGPRT + IMP
1p17 - TcHGPRT (mutant) + IMP
1yfz - TteHGPRT + IMP
1dqp - GiHGPRT + imucillin – Giardia intestinalis
1pzm - LtHGPRT + GMP – Leishmania tarentolae
1y0b - BsHGPRT + GTP – Bacillus subtilis
2fxv - BsHGPRT + GMP
3kb8 - BaHGPRT + GMP
2jky, 2jkz, 2xbu - yHGPRT + GMP
3acc - TtHGPRT + GMP
3acd - TtHGPRT + IMP
1cjb - PfHGPRT + pyrophosphate
3ozf - PfHGPRT + hypoxanthine
3ozg - PfHGPRT + inhibitor
1dqn - GiHGPRT + transition state analog
1d6n - LdAPRT + AMP derivative
Hypoxanthine-guanine PRT ternary complex
1a95 - EcHGPRT + guanine + PRPP derivative
1a96 - EcHGPRT + xanthine + PRPP derivative
1bzy - hHGPRT + inhibitor + guanine derivative
1tc2, 1i0i, 1i0l, 1i13, 1i14 – TcHGPRT + pyrimidine derivative + PRPP derivative
1p18 - TcHGPRT (mutant) + pyrimidine derivative + PRPP
1qk5 - TgHGPRT (mutant) + XMP + pyrophosphate
1fsg - TgHGPRT + guanine derivative + PRPP
1cjb - PfHGPRT + pyrophosphate + inhibitor
Quinolinic acid PRT
1o4u - TmQAPRT – Thermotoga maritima
2jbm, 3lar, 4kwv – hQAPRT
3c2e - yQAPRT
1qpo – MtQAPRT – Mycobacterium tuberculosis
Quinolinic acid PRT complex
1qap - StQAPRT + quinolinic acid
1qpr - MtQAPRT + PRPP derivative
1qpn – MtQAPRT + nicotinate mononucleotide
1qpq - MtQAPRT + quinolinic acid
3c2o - yQAPRT + quinolinic acid
3c2f - yQAPRT + PRPP
3c2r - yQAPRT + inhibitor
3c2v - yQAPRT + inhibitor + PRPP
4i9a – QAPRT + nicotinate mononucleotide – pig
2b7n – HpQAPRT + quinolinic acid – Helicobacter pylori
4kww – hQAPRT + phthalate
2b7p – HpQAPRT + phthalate
2b7q – HpQAPRT + nicotinate mononucleotide
Uracil PRT
1w30 - MtUPRT
1bd3 - TgUPRT (mutant)
1v9s - TtUPRT
2e55 - UPRT – Aquifex aeolicus
2ehj - EcUPRT
3dmp - UPRT – Burkholderia pseudomallei
Uracil PRT complex
1upu - TgUPRT (mutant) + UMP
1o5o - TmUPRT + UMP
1jlr - TgUPRT (mutant) + GTP
1bd4 - TgUPRT (mutant) + uracil
1upf - TgUPRT (mutant) + fluorouracil
1i5e, 2igb - UPRT + UMP – Bacillus caldolyticus
1jls - TgUPRT (mutant) + uracil + PRPP
1vst, 3g6w - SsUPRT + GTP + PRPP – Sulfolobus solfataricus
Adenine PRT
1qcc, 1qcd - LdAPRT – Leishmania donovani
1g2p, 1g2q – yAPRT
2dy0 - EcAPRT
4lza – APRT – Thermoanaerobacter pseudethanolicus
4m0k – APRT – Rhodothermus marinus
4mb6 – APRT – Yersinia pseudotuberculosis
Adenine PRT complex
1qb7 - LdAPRT + adenine
1qb8 - LdAPRT + AMP
1ore, 1zn8, 1zn9 - hAPRT + AMP
1mzv - LtAPRT + AMP
1zn7 - hHGPRT + adenine + PRPP
1l1q - GiAPRT + adenine derivative
1l1r - GiAPRT + adenine derivative + PRPP
Nicotinate mononucleotide:5, 6-dimethylbenzimidazole PRT
1l4b – SeNN:DBI PRT – Salmonella enterica
4kqh - SeNN:DBI PRT (mutant)
1wx1 – TtNN:DBI PRT
3u4g – PhNN:DBI PRT
Nicotinate mononucleotide:5, 6-dimethylbenzimidazole PRT complex
1jh8, 4kpf – SeNN:DBI PRT + adenine
1l4e, 1l4f, 1l4g, 1l4h, 1l4k, 1l4l, 1l4m, 1l4n, 1l5f, 1l5k, 1l5l, 1l5m, 1l5n, 1l5o - SeNN:DBI PRT + product-aldimine complex
1jha – SeNN:DBI PRT + AMP + nicotinate
4kqi - SeNN:DBI PRT (mutant) + nicotinate + α-ribazole phosphate
1jhm – SeNN:DBI PRT + benzimidazole
1jho – SeNN:DBI PRT + NaMN + benzimidazole
1jhp – SeNN:DBI PRT + benzimidazole derivative
1jhq - SeNN:DBI PRT + NaMN + benzimidazole derivative
1jhr - SeNN:DBI PRT + NaMN + hydroxypurine
1jhu - SeNN:DBI PRT + cresol
4kqk - SeNN:DBI PRT (mutant) + cresol
1jhv - SeNN:DBI PRT + nicotinate + cresol
1jhx - SeNN:DBI PRT + phenol
1jhy - SeNN:DBI PRT + phenol + nicotinate
4kqj - SeNN:DBI PRT (mutant) + NaMN + cresol
4kqg - SeNN:DBI PRT (mutant) + cobamide
Anthranilate PRT
1o17 - SsANPRT
1khd – PcANPRT – Pectobacterium carotovorum
1v8g, 2elc - TtANPRT
1vqu - ANPRT – Nostoc
3qr9 – MtANPRT
4hkm - ANPRT – Xanthomonas campestris
4gtn – ANPRT – Acinetobacter
Anthranilate PRT complex
1kgz - PcANPRT + PRPP
1zvw - MtANPRT + PRPP
4ij1 - MtANPRT + anthranilate derivative
1zxy - SsANPRT + PRPP
3gbr - SsANPRT (mutant) + PRPP
1gxb - SsANPRT + pyrophosphate
2gvq - SsANPRT + anthranilate
3qqs, 3qs8, 3qsa, 3r6c, 3r88, 3twp, 3uu1 - MtANPRT + inhibitor + PRPP
1zyk - SsANPRT + anthranilate + PRPP
4giu, 4gkm- PfANPRT + anthranilate derivative + PRPP
ATP PRT
See ATP Phosphoribosyl Transferase
Nicotinate PRT
1vlp - yNIPRT
1ybe - NIPRT – Agrobacterium tumefaciens
1yir - NIPRT – Pseudomonas aeruginosa
1ytd, 2i1o - TaNIPRT – Thermoplasma acidophilum
2bpq - MtNIPRT
2im5 - NIPRT – Porphyromonas gingivalis
3os4 - NIPRT – Yersinia pestis
4hl7 - VcNIPRT
Nicotinate PRT complex
1yte - TaNIPRT + PRPP
1ytk - TaNIPRT + NAMN
4mzy – NIPRT + malonate + Pi
Nicotinamide PRT
2gvl - mNMPRT – mouse
2g95 - NMPRT - rat
2h3b – mNMPRT (mutant)
2e5b – hNMPRT
Nicotinamide PRT complex
2h3d - mNMPRT + NMN
2gvg - hNMPRT + NMN
2g96 - rNMPRT + NMN
2g97, 3g8e - rNMPRT + FK-866
2gvj - hNMPRT + FK-866
2e5c - hNMPRT + PRPP
2e5d - hNMPRT + nicotinamide
3dgr - hNMPRT + ADP analog
4jnm, 4jr5, 4kfn, 4kfo, 4kfp, 4lts, 4lv9, 4lva, 4lvb, 4lvd, 4lvf, 4lvg, 4lww, 4m6p, 4m6q, 4n9b, 4n9c, 4n9d, 4n9e - hNMPRT + inhibitor
3dhd, 3dhf - hNMPRT + pyrophosphate + NMN
3dkj, 3dkl - hNMPRT + benzamide + PRPP
