Purine repressor (PurR) is a member of the lac repressor family. PurP binds DNA via a highly conserved helix-turn-helix at the N terminal (DBD). PurP contains a co-repressor binding domain as well (CBD). PurP binds to a 16-bp operator sequence and co-regulates genes which are involved in the biosynthesis of purine and pyrimidine nucleotides.
3D structures of purine repressor
Updated on 23-September-2014
1pru, 1prv - EcPurR DBD – Escherichia coli - NMR
1dbq - EcPurR CBD + Mg - NMR
1jhz - EcPurR CBD (mutant) + Mg
PurP complex with DNA and nucleotide
1pnr, 1bdi, 1qp0, 1qp4, 1qpz, 1qqb - EcPurR + DNA + hypoxanthine
1bdh, 2pud, 2pug, 1vpw, 1qp7, 1qqa, 1jfs, 1jft, 1jh9 - EcPurR (mutant) + DNA + hypoxanthine
1wet - EcPurR + DNA + guanine
2pua - EcPurR (mutant) + DNA + methylpurine
2pub, 2pue - EcPurR (mutant) + DNA + adenine
2puc, 2puf - EcPurR (mutant) + DNA + guanine
1zay - EcPurR + DNA + hypoxanthine + di-imino-purine
