Pyridoxal kinase

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Image:3keu.png
Crystal structure of human pyridoxal kinase complex with Mg+2 ion, ATP and pyridoxal-5’-phosphate 3keu

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Pyridoxal kinase (PDK) catalyzes the transfer of phosphate (Pi) from ATP to 5’ alcohol of pyridoxine, pyridoxamine and pyridoxal.

Contents

3D Structures of pyridoxal kinase

Updated on 20-August-2014

Pyridoxal kinase

1lhp – sPDK – sheep
2f7k – hPDK - human
2ddm – EcPDK – Escherichia coli
3h74 – LpPDK – Lactobacillus planarum
3zs7 – PDK – Trypanosoma brucei
4c5j – SaPDK – Staphylococcus aureus

Pyridoxal kinase complex with pyridoxal compounds

1rft – sPDK + Zn + K + AMPPCP + pyridoxamine
1rfu – sPDK + Zn + ADP + pyridoxal-5’-phosphate
2ddw – EcPDK + pyridoxal
4c5l – SaPDK + pyridoxal
4c5n – SaPDK + pyridoxal + AMPPCP
3fhx – hPDK (mutant) + Mg + Na + ATP + pyridoxal + pyridoxal-5’-phosphate
3keu – hPDK + Mg + ATP + pyridoxal-5’-phosphate

Other pyridoxal kinase complexes

1lhr – sPDK + Zn + K + ATP
1rfv – sPDK + Zn + ADP
1ygj, 1ygk, 1yhj – sPDK + roscovitine
2ajp – hPDK + Mg + ANP
2ddo – EcPDK + Mg + ATP + Pi
2i5b – PDK + ADP – Bacillus subtilis
2yxt – hPDK + Na + Pi
2yxu – hPDK + Mg + Na + ATP + Pi
3fhy – hPDK (mutant) + Mg + Na + ATP
3hyo – LpPDK + Mg + ADP
3ibq – LpPDK + Mg + ATP
4en4 – hPDK + Mg + ATP + ginkotoxin
4eoh – hPDK + Na + theophylline
4c5k – SaPDK + ADP
4c5m – SaPDK + AMPPCP

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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