1mqx

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Template:STRUCTURE 1mqx

Contents

NMR Solution Structure of Type-B Lantibiotics Mersacidin in MeOH/H2O Mixture

Template:ABSTRACT PUBMED 12562773

Function

[MRSA_BACSY] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.

About this Structure

1mqx is a 1 chain structure with sequence from Bacillus sp. hil-y85/54728. Full experimental information is available from OCA.

Reference

  • Hsu ST, Breukink E, Bierbaum G, Sahl HG, de Kruijff B, Kaptein R, van Nuland NA, Bonvin AM. NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity. J Biol Chem. 2003 Apr 11;278(15):13110-7. Epub 2003 Jan 31. PMID:12562773 doi:10.1074/jbc.M211144200

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