1mlw

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1mlw, resolution 1.71Å

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Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)

Contents

Overview

Tryptophan hydroxylase oxidizes L-tryptophan to 5-hydroxy-L-tryptophan in the rate-determining step of serotonin biosynthesis. We have determined the X-ray crystal structure (1.7 A) of a truncated functional form of human tryptophan hydroxylase with the bound cofactor analogue 7,8-dihydro-L-biopterin, providing the first atomic-resolution information for the catalytic domain of this important enzyme. Comparison of the three-dimensional structures of all three members of the aromatic amino acid hydroxylase family--tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase--reveals important differences at the active sites.

Disease

Known disease associated with this structure: Unipolar depression, susceptibility to OMIM:[607478]

About this Structure

1MLW is a Single protein structure of sequence from Homo sapiens with and as ligands. The following page contains interesting information on the relation of 1MLW with [Phenylalanine Hydroxylase]. Active as Tryptophan 5-monooxygenase, with EC number 1.14.16.4 Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin., Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC, Biochemistry. 2002 Oct 22;41(42):12569-74. PMID:12379098

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