1mq0

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Image:1mq0.gif

1mq0, resolution 2.40Å

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Crystal Structure of Human Cytidine Deaminase

Contents

Overview

Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.

Disease

Known disease associated with this structure: Anemia, congenital dyserythropoietic, type I OMIM:[607465]

About this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Cytidine deaminase, with EC number 3.5.4.5 Full crystallographic information is available from OCA.

Reference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149

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