3lox

From Proteopedia

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Template:STRUCTURE 3lox

Contents 1 HCV NS3-4a protease domain with a ketoamide inhibitor derivative of Boceprevir bound 2 About this Structure 3 See Also 4 Reference

HCV NS3-4a protease domain with a ketoamide inhibitor derivative of Boceprevir bound

Template:ABSTRACT PUBMED 20303756

About this Structure

3lox is a 4 chain structure with sequence from Hepatitis c virus subtype 1a. Full crystallographic information is available from OCA.

See Also

• Proliferating Cell Nuclear Antigen

Reference

• Bennett F, Huang Y, Hendrata S, Lovey R, Bogen SL, Pan W, Guo Z, Prongay A, Chen KX, Arasappan A, Venkatraman S, Velazquez F, Nair L, Sannigrahi M, Tong X, Pichardo J, Cheng KC, Girijavallabhan VM, Saksena AK, Njoroge FG. The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2617-21. Epub 2010 Feb 19. PMID:20303756 doi:10.1016/j.bmcl.2010.02.063