1nik

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Image:1nik.gif

1nik, resolution 4.10Å

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Wild Type RNA Polymerase II

Overview

The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.

About this Structure

1NIK is a Protein complex structure of sequences from Saccharomyces cerevisiae with as ligand. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.

Reference

Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription., Bushnell DA, Kornberg RD, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6969-73. Epub 2003 May 13. PMID:12746498

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