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3qlf

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Image:3qlf.png

Template:STRUCTURE 3qlf

Contents

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5

Template:ABSTRACT PUBMED 17355866

About this Structure

3qlf is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA.

See Also

Reference

  • Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure. 2007 Mar;15(3):299-311. PMID:17355866 doi:10.1016/j.str.2007.01.015
  • Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20;15(10):1015-22. PMID:18940662 doi:10.1016/j.chembiol.2008.09.007

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OCA

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