2bo9

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spinqualitylabelsall models 2bo9, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

HUMAN CARBOXYPEPTIDASE A4 IN COMPLEX WITH HUMAN LATEXIN.

Overview

The only endogenous protein inhibitor known for metallocarboxypeptidases, (MCPs) is latexin, a 25-kDa protein discovered in the rat brain. Latexin, alias endogenous carboxypeptidase inhibitor, inhibits human CPA4 (hCPA4), whose expression is induced in prostate cancer cells after treatment with, histone deacetylase inhibitors. hCPA4 is a member of the A/B subfamily of, MCPs and displays the characteristic alpha/beta-hydrolase fold. Human, latexin consists of two topologically equivalent subdomains, reminiscent, of cystatins, consisting of an alpha-helix enveloped by a curved, beta-sheet. These subdomains are packed against each other through the, helices and linked by a connecting segment encompassing a third, alpha-helix. The enzyme is bound at the interface of these subdomains. The, ... [(full description)]

About this Structure

2BO9 is a [Protein complex] structure of sequences from [Homo sapiens] with NAG, ZN, VAL, MPD and ACN as [ligands]. This structure superseeds the now removed PDB entry 2BK7. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin., Pallares I, Bonet R, Garcia-Castellanos R, Ventura S, Aviles FX, Vendrell J, Gomis-Ruth FX, Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3978-83. Epub 2005 Feb 28. PMID:15738388

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