4dru

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Image:4dru.png

Template:STRUCTURE 4dru

Contents

HCV NS5B in complex with macrocyclic INDOLE INHIBITOR

Template:ABSTRACT PUBMED 22473861

About this Structure

4dru is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

Reference

  • Cummings MD, Lin TI, Hu L, Tahri A, McGowan D, Amssoms K, Last S, Devogelaere B, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, Van Emelen K, Nyanguile O, Simmen K, Raboisson P, Vendeville S. Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties. Angew Chem Int Ed Engl. 2012 Mar 30. doi: 10.1002/anie.201200110. PMID:22473861 doi:10.1002/anie.201200110

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