Selectin or CD62 are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain
and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: E-selectin found in endothelial cells; L-selectin found in leukocytes; P-selectin found in platelets. Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the bleed vessel walls, slowing their motion and enabling them to enter the site of infection.
3D structures of selectin
Updated on 20-August-2014
P-selectin
1fsb – hCD62P EGF domain – human - NMR
1g1q – hCD62P EGF domain
1g1r – hCD62P EGF domain + tetrasaccharide
1g1s – hCD62P EGF domain +P-selectin glycoprotein ligand peptide
4gxb – hCD62P intracellular domain + sorting nexin-17
L-selectin
3cfw – hCD62L EGF domain
2lgf – hCD62L calmodulin-binding domain + calmodulin
E-selectin
1esl – hCD62E EGF domain
1g1t – hCD62E EGF domain + tetrasaccharide
