Function
Squalene synthase (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol.
Disease
Relevance
Structural highlights
3D structures of squalene synthase
Updated on 24-September-2014
SQS
3vj8, 3vjb – hSQS – human
1ezf – hSQS (mutant)
SQS complexes
3lee – hSQS + Mg + bisphosphonate inhibitor
3asx, 3q2z, 3q30 – hSQS + Mg + PO4 + inhibitor
3vj9, 3vja – hSQS + Ni
3vjc – hSQS + Mg + PO4 + zaragozic acid
3v66 – hSQS + PO4 + inhibitor
3wef – hSQS + FPP analog
3weg – hSQS + Mg + FPP analog
3weh – hSQS + Mg + presqualene pyrophosphate
3wei – hSQS (mutant) + Mn + presqualene pyrophosphate
3wej, 3wek – hSQS (mutant) + Mg + presqualene pyrophosphate
References
