Tryptase inhibitors (TI) are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
3D structures of tryptase inhibitor
Leech-derived tryptase inhibitor
1ldt – MlTI + trypsin – Medicinal leech
1an1 - MlTI (mutant) + trypsin
2kmo, 2kmp, 2kmq, 2kmr – MlTI - NMR
Tick-derived tryptase inhibitor
2uux – tTI residues 44-96 – tick
2uuy - tTI + trypsin
2lfk, 2lfl – tTI - NMR