Function
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a Zn-dependent protein which participates in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharides into the membrane of Gram negative bacteria. LpxC catalyzes the conversion of UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetylglucosamine to UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-glucosamine.
Disease
Relevance
Structural highlights
3D Structures of UDP-3-O-acyl-N-acetylglucosamine deacetylase
Updated on 29-July-2014
LpxC complexes
1yh8 – AaLpxC (mutant) + Zn + palmitate – Aquifex aeolicus
1p42 – AaLpxC (mutant) + Zn + myristate
1yhc – AaLpxC (mutant) + Zn + palmitate + cacodylate
2j65 – AaLpxC (mutant) + Zn + myristate + UDP
2ier – AaLpxC (mutant) + Zn + palmitate + UDP
2ies – AaLpxC (mutant) + Zn + palmitate + pyrophosphate
4mdt – EcLpxC + Zn + UDP-(3-O-(R-3-hydroxymyristoyl))-glucosamine – Escherichia coli
LpxC complex with inhibitor
1xxe – AaLpxC + Zn + inhibitor - NMR
3p76 – AaLpxC + Zn + inhibitor
2go4, 3p3c – AaLpxC (mutant) + Zn + inhibitor
2go3 – AaLpxC (mutant) + Zn + myristate + cacodylate + imidazole
2o3z – AaLpxC (mutant) + Zn + benzoate derivative
2jt2 – AaLpxC (mutant) + Zn + antibiotic - NMR
2ves – PaLpxC (mutant) + Zn + inhibitor – Pseudomonas aeruginosa - NMR
3p3e, 3u1y, 3uhm, 4lcf, 4lcg, 4lch – PaLpxC (mutant) + Zn + inhibitor
4j3d, 4fw3, 4fw4, 4fw5, 4fw6, 4fw7 – PaLpxC + Zn + inhibitor
3nzk – LpxC + Zn + inhibitor – Yersinia enterocolitica
3p3g, 3ps1, 3ps2, 3ps3, 4mqy, 4is9, 4isa – EcLpxC + Zn + inhibitor
References
