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2l2z

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Template:STRUCTURE 2l2z

Contents

Thiostrepton, reduced at N-CA bond of residue 14

Function

[THCL_STRAJ] Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).

About this Structure

2l2z is a 1 chain structure with sequence from Streptomyces azureus. Full experimental information is available from OCA.

Reference

  • Jonker HR, Baumann S, Wolf A, Schoof S, Hiller F, Schulte KW, Kirschner KN, Schwalbe H, Arndt HD. NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site. Angew Chem Int Ed Engl. 2011 Mar 28;50(14):3308-12. doi: 10.1002/anie.201003582. , Epub 2011 Mar 1. PMID:21365717 doi:10.1002/anie.201003582

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OCA

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