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2lo9

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Revision as of 04:21, 12 September 2013 by OCA (Talk | contribs)

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Template:STRUCTURE 2lo9

1 NMR solution structure of Mu-contoxin BuIIIB
2 Function
3 About this Structure
4 Reference

NMR solution structure of Mu-contoxin BuIIIB

Template:ABSTRACT PUBMED 23557677

Function

[CM3B_CONBU] Mu-conotoxins block voltage-gated sodium channels. Extremely potent inhibitor of Nav1.4/SCN4A. The inhibition is very slowly reversible.

About this Structure

2lo9 is a 1 chain structure. Full experimental information is available from OCA.

Reference

Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Mammalian Neuronal Sodium Channel Blocker mu-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency. ACS Chem Biol. 2013 Apr 16. PMID:23557677 doi:10.1021/cb300674x