2loc

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Template:STRUCTURE 2loc

Contents

Conotoxin analogue [D-Ala2]BuIIIB

Template:ABSTRACT PUBMED 23557677

Function

[CM3B_CONBU] Mu-conotoxins block voltage-gated sodium channels. Extremely potent inhibitor of Nav1.4/SCN4A. The inhibition is very slowly reversible.

About this Structure

2loc is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Mammalian Neuronal Sodium Channel Blocker mu-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency. ACS Chem Biol. 2013 Apr 16. PMID:23557677 doi:10.1021/cb300674x

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