2lv3

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Template:STRUCTURE 2lv3

Contents 1 Structure-functional characterization of Grx domain of Mus musculus TGR 2 Function 3 About this Structure 4 Reference

Structure-functional characterization of Grx domain of Mus musculus TGR

Template:ABSTRACT PUBMED 23300818

Function

[TRXR3_MOUSE] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.^{[1] [2]}

About this Structure

2lv3 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

• Dobrovolska O, Shumilina E, Gladyshev VN, Dikiy A. Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. PLoS One. 2012;7(12):e52914. doi: 10.1371/journal.pone.0052914. Epub 2012 Dec 26. PMID:23300818 doi:10.1371/journal.pone.0052914

1. ↑ Sun QA, Kirnarsky L, Sherman S, Gladyshev VN. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3673-8. Epub 2001 Mar 20. PMID:11259642 doi:10.1073/pnas.051454398
2. ↑ Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem. 2005 Jul 15;280(28):26491-8. Epub 2005 May 18. PMID:15901730 doi:M503638200