2lqr

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Template:STRUCTURE 2lqr

Contents

NMR structure of Ig3 domain of palladin

Template:ABSTRACT PUBMED 23806659

Function

[PALLD_MOUSE] Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific May be required for the initiation of neural tube closure.[1] [2] [3] [4]

About this Structure

2lqr is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  • Beck MR, Dixon RD, Goicoechea SM, Murphy GS, Brungardt JG, Beam MT, Srinath P, Patel J, Mohiuddin J, Otey CA, Campbell SL. Structure and Function of Palladin's Actin Binding Domain. J Mol Biol. 2013 Jun 25. pii: S0022-2836(13)00395-1. doi:, 10.1016/j.jmb.2013.06.016. PMID:23806659 doi:10.1016/j.jmb.2013.06.016
  1. ↑ Parast MM, Otey CA. Characterization of palladin, a novel protein localized to stress fibers and cell adhesions. J Cell Biol. 2000 Aug 7;150(3):643-56. PMID:10931874
  2. ↑ Luo H, Liu X, Wang F, Huang Q, Shen S, Wang L, Xu G, Sun X, Kong H, Gu M, Chen S, Chen Z, Wang Z. Disruption of palladin results in neural tube closure defects in mice. Mol Cell Neurosci. 2005 Aug;29(4):507-15. PMID:15950489 doi:10.1016/j.mcn.2004.12.002
  3. ↑ Rachlin AS, Otey CA. Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin. J Cell Sci. 2006 Mar 15;119(Pt 6):995-1004. Epub 2006 Feb 21. PMID:16492705 doi:10.1242/jcs.02825
  4. ↑ Liu XS, Luo HJ, Yang H, Wang L, Kong H, Jin YE, Wang F, Gu MM, Chen Z, Lu ZY, Wang ZG. Palladin regulates cell and extracellular matrix interaction through maintaining normal actin cytoskeleton architecture and stabilizing beta1-integrin. J Cell Biochem. 2007 Apr 1;100(5):1288-300. PMID:17115415 doi:10.1002/jcb.21126

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