1ikp

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Template:STRUCTURE 1ikp

Contents

Pseudomonas Aeruginosa Exotoxin A, P201Q, W281A mutant

Template:ABSTRACT PUBMED 11734000

Function

[TOXA_PSEAE] An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.[1]

About this Structure

1ikp is a 1 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

  • Wedekind JE, Trame CB, Dorywalska M, Koehl P, Raschke TM, McKee M, FitzGerald D, Collier RJ, McKay DB. Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity. J Mol Biol. 2001 Dec 7;314(4):823-37. PMID:11734000 doi:10.1006/jmbi.2001.5195
  • Brandhuber BJ, Allured VS, Falbel TG, McKay DB. Mapping the enzymatic active site of Pseudomonas aeruginosa exotoxin A. Proteins. 1988;3(3):146-54. PMID:3151219 doi:http://dx.doi.org/10.1002/prot.340030303
  1. ↑ Jorgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Rod Merrill A. Cholix toxin, a novel ADP-ribosylating factor from vibrio cholerae. J Biol Chem. 2008 Feb 25;. PMID:18276581 doi:M710008200

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