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3ey4
From Proteopedia
Contents |
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
Disease
[DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Function
[DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
About this Structure
3ey4 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Categories: 11-beta-hydroxysteroid dehydrogenase | Homo sapiens | Jordan, S R. | Li, V. | Zhang, J D. | Alpha beta | Drug design | Endoplasmic reticulum | Glycoprotein | Inhibitor | Lipid metabolism | Membrane | Nadp | Oxidoreductase | Rossmann fold | Signal-anchor | Steroid metabolism | Transmembrane
