3d5q

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Template:STRUCTURE 3d5q

Contents 1 Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor

Template:ABSTRACT PUBMED 18789704

Disease

[DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).

Function

[DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

About this Structure

3d5q is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hydroxysteroid dehydrogenase

Reference

• Tu H, Powers JP, Liu J, Ursu S, Sudom A, Yan X, Xu H, Meininger D, Degraffenreid M, He X, Jaen JC, Sun D, Labelle M, Yamamoto H, Shan B, Walker NP, Wang Z. Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem. 2008 Oct 1;16(19):8922-31. Epub 2008 Aug 29. PMID:18789704 doi:10.1016/j.bmc.2008.08.065