2ykd

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Template:STRUCTURE 2ykd

Contents

STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS

Template:ABSTRACT PUBMED 21141948

Function

[MATRX_HRSVA] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.[1]

About this Structure

2ykd is a 1 chain structure with sequence from Human respiratory syncytial virus. Full crystallographic information is available from OCA.

Reference

  • McPhee HK, Carlisle JL, Beeby A, Money VA, Watson SM, Yeo RP, Sanderson JM. Influence of lipids on the interfacial disposition of respiratory syncytical virus matrix protein. Langmuir. 2011 Jan 4;27(1):304-11. Epub 2010 Dec 9. PMID:21141948 doi:10.1021/la104041n
  1. ↑ Ghildyal R, Mills J, Murray M, Vardaxis N, Meanger J. Respiratory syncytial virus matrix protein associates with nucleocapsids in infected cells. J Gen Virol. 2002 Apr;83(Pt 4):753-7. PMID:11907323

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