3mpx
From Proteopedia
Crystal structure of the DH and PH-1 domains of human FGD5
Function
[FGD5_HUMAN] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
About this Structure
3mpx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Arrowsmith, C H. | Bochkarev, A. | Bountra, C. | Crombet, L. | Edwards, A M. | Nedyalkova, L. | Park, H. | SGC, Structural Genomics Consortium. | Shen, Y. | Tempel, W. | Tong, Y. | Weigelt, J. | Dh domain | Lipid binding protein | Ph domain | Sgc | Structural genomics consortium
