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3kbl
From Proteopedia
Contents |
Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans N169A mutant at 2.28 A resolution
Template:ABSTRACT PUBMED 20223220
Function
[GLD1_CAEEL] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.
About this Structure
3kbl is a 4 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
- Beuck C, Szymczyna BR, Kerkow DE, Carmel AB, Columbus L, Stanfield RL, Williamson JR. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. Structure. 2010 Mar 10;18(3):377-89. PMID:20223220 doi:10.1016/j.str.2009.12.016
Categories: Caenorhabditis elegans | Beuck, C. | Carmel, A B. | Columbus, L. | Kerkow, D E. | Stanfield, R L. | Szymczyna, B R. | Williamson, J R. | Developmental protein | Differentiation | Gld-1 | Helix-turn-helix motif | Hydrophobic homodimer interface | Meiosis | N169a mutant | Oogenesis | Perpendicular stacking of protomer | Protein binding | Qua1 homodimerization domain | Rna-binding | Translation regulation
